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KMID : 0363220150530100760
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Korean Journal of Dermatology
2015 Volume.53 No. 10 p.760 ~ p.765
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Combination Therapy of Topical CCB (Combination of Calcipotriol and Betamethasone Dipropionate) Gel and Narrowband Ultraviolet B (NBUVB) in the Treatment of Vitiligo: An Intraindividual Right-Versus-Left Comparison Study with Topical Betamethasone Dipropionate over 48 Weeks
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Ha Seung-Min
Song Ki-Hoon
Kim Ki-Ho
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Abstract
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Background: In the treatment of vitiligo, topical corticosteroids are known to be effective, but are associated with serious adverse effects. Many studies have shown that topical calcipotriol is a promising therapeutic modality in vitiligo. In some studies, combined calcipotriol and betamethasone dipropionate ointment has been shown to be a more effective and well tolerated treatment for vitiligo. The combination therapy seems to synergistically act as an immunosuppressive and a pigment restorative agent.
Objective: We investigated the clinical efficacy of CCB (Combination Calcipotriol and Betamethasone dipropionate) gel compared with that of betamethasone dipropionate alone in the repigmentation of vitiligo.
Methods: In an intraindividual right-left comparison study (n=20), a CCB gel was applied once daily to a lesion on one side, and betamethasone dipropionate cream was applied to a lesion on the other side. The degree of repigmentation was assessed according to the Vitiligo Area Scoring Index (VASI) at baseline, 4, 12, 24, and 48 weeks.
Results: The CCB gel treated group showed a remarkably improved therapeutic outcome compared to the betamethasone dipropionate monotherapy group: the percentages of VASI relative to the baseline at CCB gel treated sites were 82.73±8.17%, 70.45±14.05%, 62.73±17.52%, and 56.24±18.49% at 4, 12, 24, and 48 weeks after treatment, respectively; while those of the other sites receiving betamethasone dipropionate were 89.55±7.24%, 84.55±10.60%, 77.73±14.38%, and 73.48±12.93%. Adverse effects such as atrophy and burning sensations were much less after CCB gel treatment than after betamethasone monotherapy.
Conclusion: CCB gel is more effective and tolerable than betamethasone dipropionate monotherapy in repigmentation therapy for vitiligo.
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KEYWORD
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Betamethasone dipropionate, Calcipotriol, Combination therapy, Repigmentation, Vitiligo
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